[14:38] <lukasm> John72: Yes, you can set parameters directly with ovs-vsctl, independently of netplan. Netplan will only cleanup (and restore) interfaces and settings on things it set itself. Those settings will be marked with a "netplan/" tag in "other_config".
[14:40] <lukasm> If you're modifying a interface created by netplan, you might need to restore that configuration after reboot, especially after the "netplan-ovs-cleanup.service" systemd unit has run. E.g. by having your own systemd unit/service to define those ovs-vsctl commands and depending on the netplan-ovs-cleanup.service via "After=netplan-ovs-cleanup.service"